Developmentally degraded cortical temporal processing restored by training

Nat Neurosci. 2009 Jan;12(1):26-8. doi: 10.1038/nn.2239. Epub 2008 Dec 14.

Abstract

Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally impaired animals as juveniles or young adults. Re-normalized cortical temporal response characteristics were sustained long after training cessation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation*
  • Animal Husbandry
  • Animals
  • Animals, Newborn
  • Auditory Cortex / growth & development
  • Auditory Cortex / physiopathology*
  • Critical Period, Psychological*
  • Noise
  • Perceptual Disorders / etiology
  • Perceptual Disorders / physiopathology*
  • Rats
  • Time Perception*