Abstract
The recent description of somatic cell reprogramming to an embryonic stem (ES) cell-like phenotype, termed induced pluripotent stem (iPS) cell technology, presents an exciting potential venue toward cell-based therapeutics and disease models for neurodegenerative disorders. Two recent studies (Dimos et al. and Ebert et al.) describe the initial characterization of neurodegenerative disease patient-derived iPS cell cultures as proof of concept for the utility of this technology.
MeSH terms
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Animals
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Cell Culture Techniques / methods
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Cell Culture Techniques / trends
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Cell Dedifferentiation / physiology*
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Cell Lineage / physiology
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Embryonic Stem Cells / physiology
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Embryonic Stem Cells / transplantation*
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Humans
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Neurodegenerative Diseases / therapy*
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Pluripotent Stem Cells / physiology
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Pluripotent Stem Cells / transplantation*
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Stem Cell Transplantation / methods*
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Stem Cell Transplantation / trends*
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Transplantation, Autologous / methods
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Transplantation, Autologous / trends