Abstract
Following CNS injury, in an apparently counterintuitive response, scar tissue formation inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar-modulating treatments have become a leading therapeutic goal in the field of spinal cord injury. However, increasing evidence suggests a beneficial role for this scar tissue as part of the endogenous local immune regulation and repair process. How can these opposing effects be reconciled? Perhaps it is all a matter of timing.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Brain Injuries / physiopathology*
-
Brain Injuries / therapy
-
Cicatrix / physiopathology*
-
Cicatrix / prevention & control
-
Cicatrix / therapy
-
Extracellular Matrix Proteins / metabolism
-
Gliosis / physiopathology*
-
Gliosis / prevention & control
-
Gliosis / therapy
-
Growth Cones / physiology
-
Growth Cones / ultrastructure
-
Humans
-
Nerve Regeneration / physiology*
-
Neurogenesis / physiology
-
Neuroglia / physiology
-
Neuroglia / ultrastructure
-
Spinal Cord Injuries / physiopathology*
-
Spinal Cord Injuries / therapy
Substances
-
Extracellular Matrix Proteins