The pre/post LTP debate

Neuron. 2009 Aug 13;63(3):281-4. doi: 10.1016/j.neuron.2009.07.020.

Abstract

The pre/post debate involves the question of whether long-term potentiation (LTP) is mediated by enhancement of release, enhancement of postsynaptic receptors, or both. Recent papers have presented evidence for purely postsynaptic or purely presynaptic changes, and a paper by Ahmed and Siegelbam (in this issue of Neuron) suggests a mechanism by which release is enhanced. This debate is increasingly constrained by technical advances that allow central synapses to be studied with increasing precision. A possible of way of reconciling conflicting evidence is suggested.

Publication types

  • Comment

MeSH terms

  • Animals
  • Long-Term Potentiation / physiology*
  • Mice
  • Models, Neurological
  • Synapses / physiology*
  • Synaptic Transmission / physiology*