Caffeine increases cerebral cortical activity in preterm infants

Sirma Supcun; Patrizia Kutz; Wolfgang Pielemeier; Claudia Roll

doi:10.1016/j.jpeds.2009.10.033

Caffeine increases cerebral cortical activity in preterm infants

J Pediatr. 2010 Mar;156(3):490-1. doi: 10.1016/j.jpeds.2009.10.033.

Authors

Sirma Supcun¹, Patrizia Kutz, Wolfgang Pielemeier, Claudia Roll

Affiliation

¹ Department of Neonatology and Pediatric Intensive Care, Vest Children's Hospital, University of Witten-Herdecke, Datteln, Germany.

PMID: 20176190
DOI: 10.1016/j.jpeds.2009.10.033

Abstract

Caffeine improves the rate of survival without neurodevelopmental disability in preterm infants. The mechanisms underlying neuroprotection are incompletely understood. In 51 preterm infants studied by amplitude-integrated electroencephalography from 2 hours before to 2 hours after intravenous caffeine administration, we found that caffeine increases amplitudes and periods of continuity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Caffeine / administration & dosage
Caffeine / pharmacology*
Cerebral Cortex / drug effects
Cerebral Cortex / physiology*
Electroencephalography* / drug effects
Humans
Infant, Newborn
Infant, Premature / physiology*
Infusions, Intravenous
Neuroprotective Agents / administration & dosage
Neuroprotective Agents / pharmacology*

Substances

Neuroprotective Agents
Caffeine