Abstract
The identification of several mutations causing familial forms of Parkinson's disease (PD) has led to the creation of multiple lines of mice expressing similar genetic alterations. These models present a unique opportunity for understanding pathophysiological mechanisms leading to PD in a mammalian brain and provide models that are suitable for the preclinical testing of new therapies. Different lines of mice recapitulate the symptoms and pathological features of PD to various extents. This chapter examines their respective advantages and highlights some of the key findings that have already emerged from the analysis of these new models of PD.
Copyright © 2010 Elsevier B.V. All rights reserved.
MeSH terms
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Animals
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Behavior, Animal / physiology
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Brain Chemistry / physiology
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Calcium-Calmodulin-Dependent Protein Kinase Type 2 / genetics
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Catecholamines / physiology
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Cricetinae
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Disease Models, Animal
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Dopamine / physiology
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Humans
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Mice
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Parkinson Disease / genetics*
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Parkinson Disease / pathology
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Parkinson Disease / psychology
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Platelet-Derived Growth Factor / genetics
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Prions / biosynthesis
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Prions / genetics
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Promoter Regions, Genetic / genetics
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Protein Serine-Threonine Kinases / genetics
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Psychomotor Performance / physiology
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Tyrosine 3-Monooxygenase / genetics
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alpha-Synuclein / biosynthesis
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alpha-Synuclein / genetics
Substances
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Catecholamines
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Platelet-Derived Growth Factor
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Prions
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alpha-Synuclein
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Tyrosine 3-Monooxygenase
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Lrrk2 protein, mouse
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Protein Serine-Threonine Kinases
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Dopamine