Abstract
Two major neuronal populations were revealed in rat dorsal root ganglia, immunoreactive for either peripherin, or neurofilament triplet proteins (adult L2 ganglia: 66.2% and 25.6%, mainly small and large diameter cells, respectively), together with a minor, double-immunostained population (L2: 8.1%, mainly intermediate-size neurons). After capsaicin treatment, a striking expansion in the latter population was seen (L2: 22.0%) together with a significant increase in size, restricted to the same population and the (remaining) peripherin-only immunoreactive neurons. Calcitonin gene-related peptide (CGRP) immunoreactivity was revealed in neurons of all 3 groups, in both normal and capsaicin-treated rats.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcitonin Gene-Related Peptide / metabolism
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Capsaicin / pharmacology*
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Cytoskeleton / drug effects*
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Ganglia, Spinal / cytology
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Ganglia, Spinal / drug effects
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Ganglia, Spinal / metabolism*
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Immunohistochemistry
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Intermediate Filament Proteins / metabolism*
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Intermediate Filaments / drug effects*
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Membrane Glycoproteins*
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Nerve Tissue Proteins*
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Neurofilament Proteins
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Neurons, Afferent / cytology
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Neurons, Afferent / drug effects
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Neurons, Afferent / metabolism*
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Peripherins
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Rats
Substances
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Intermediate Filament Proteins
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Membrane Glycoproteins
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Nerve Tissue Proteins
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Neurofilament Proteins
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Peripherins
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Calcitonin Gene-Related Peptide
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Capsaicin