Identification by anti-idiotype antibodies of an intracellular membrane protein that recognizes a mammalian endoplasmic reticulum retention signal

Nature. 1990 Jun 7;345(6275):495-502. doi: 10.1038/345495a0.

Abstract

Monoclonal antibodies were raised against antibodies to distinct carboxy-terminal KDEL sequences of two soluble, resident endoplasmic reticulum proteins. These anti-idiotype reagents recognize an intrinsic membrane protein with characteristics expected of a receptor responsible for the recognition and return of resident proteins to the endoplasmic reticulum.

Publication types

  • Retracted Publication

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Anti-Idiotypic / immunology*
  • Antibodies, Monoclonal / immunology
  • Brefeldin A
  • Cell Compartmentation* / drug effects
  • Cyclopentanes / pharmacology
  • Endoplasmic Reticulum / physiology*
  • Fluorescent Antibody Technique
  • Hybridomas / physiology
  • Membrane Proteins / physiology
  • Mice
  • Molecular Sequence Data
  • Molecular Weight
  • Oligopeptides / immunology
  • Proteins / metabolism*
  • Receptors, Cell Surface / immunology
  • Receptors, Cell Surface / physiology*
  • Receptors, Peptide*
  • Solubility

Substances

  • Antibodies, Anti-Idiotypic
  • Antibodies, Monoclonal
  • Cyclopentanes
  • KDEL receptor
  • Membrane Proteins
  • Oligopeptides
  • Proteins
  • Receptors, Cell Surface
  • Receptors, Peptide
  • Brefeldin A