HDAC inhibition prevents Rd1 mouse photoreceptor degeneration

Adv Exp Med Biol. 2012:723:107-13. doi: 10.1007/978-1-4614-0631-0_15.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Death / drug effects
  • Cell Death / physiology
  • Cells, Cultured
  • Cyclic Nucleotide Phosphodiesterases, Type 6 / genetics*
  • Gene Expression / physiology
  • Histone Deacetylase 1 / antagonists & inhibitors*
  • Histone Deacetylase 1 / metabolism
  • Histone Deacetylase Inhibitors / pharmacology
  • Hydroxamic Acids / pharmacology*
  • Mice
  • Mice, Inbred C3H
  • Neuroprotective Agents / pharmacology
  • Photoreceptor Cells, Vertebrate* / drug effects
  • Photoreceptor Cells, Vertebrate* / metabolism
  • Photoreceptor Cells, Vertebrate* / pathology
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases / metabolism
  • Retinitis Pigmentosa / drug therapy*
  • Retinitis Pigmentosa / genetics
  • Retinitis Pigmentosa / metabolism

Substances

  • Histone Deacetylase Inhibitors
  • Hydroxamic Acids
  • Neuroprotective Agents
  • trichostatin A
  • Parp1 protein, mouse
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases
  • Cyclic Nucleotide Phosphodiesterases, Type 6
  • Pde6b protein, mouse
  • Hdac1 protein, mouse
  • Histone Deacetylase 1