Abstract
Neuropeptide Y (NPY) is found in the C-cells yet is absent from the B-cells of amphibian sympathetic ganglia. The effects of this peptide on both cell types were studied using the whole-cell patch-clamp recording technique. Although NPY had little effect on the B-cells, it opened inwardly-rectifying K(+)-channels in C-cells. This effect of the peptide on C-cell K(+)-channels was similar to that produced by muscarine and adrenaline and may be related to autoreceptor function.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Epinephrine / pharmacology
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Ganglia, Sympathetic / cytology
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Ganglia, Sympathetic / physiology*
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In Vitro Techniques
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Membrane Potentials / drug effects
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Muscarine / pharmacology*
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Neurons / cytology
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Neurons / drug effects
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Neurons / physiology*
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Neuropeptide Y / pharmacology*
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Potassium Channels / drug effects
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Potassium Channels / physiology*
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Rana pipiens
Substances
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Neuropeptide Y
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Potassium Channels
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Muscarine
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Epinephrine