Neuropeptide Y activates inwardly-rectifying K(+)-channels in C-cells of amphibian sympathetic ganglia

Neurosci Lett. 1990 Sep 4;117(1-2):123-8. doi: 10.1016/0304-3940(90)90130-2.

Abstract

Neuropeptide Y (NPY) is found in the C-cells yet is absent from the B-cells of amphibian sympathetic ganglia. The effects of this peptide on both cell types were studied using the whole-cell patch-clamp recording technique. Although NPY had little effect on the B-cells, it opened inwardly-rectifying K(+)-channels in C-cells. This effect of the peptide on C-cell K(+)-channels was similar to that produced by muscarine and adrenaline and may be related to autoreceptor function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Epinephrine / pharmacology
  • Ganglia, Sympathetic / cytology
  • Ganglia, Sympathetic / physiology*
  • In Vitro Techniques
  • Membrane Potentials / drug effects
  • Muscarine / pharmacology*
  • Neurons / cytology
  • Neurons / drug effects
  • Neurons / physiology*
  • Neuropeptide Y / pharmacology*
  • Potassium Channels / drug effects
  • Potassium Channels / physiology*
  • Rana pipiens

Substances

  • Neuropeptide Y
  • Potassium Channels
  • Muscarine
  • Epinephrine