Neuropeptide Y and its role in CNS disease and repair

Exp Neurol. 2012 Dec;238(2):265-72. doi: 10.1016/j.expneurol.2012.09.004. Epub 2012 Sep 27.

Abstract

Neuropeptide Y (NPY) is widely expressed throughout the CNS and exerts a number of important physiological functions as well as playing a role in pathological conditions such as obesity, anxiety, epilepsy, chronic pain and neurodegenerative disorders. In this review, we highlight some of the recent advances in our understanding of NPY biology and how this may help explain not only its role in health and disease, but also its possible use therapeutically.

Publication types

  • Review

MeSH terms

  • Animals
  • Central Nervous System Diseases / drug therapy*
  • Central Nervous System Diseases / metabolism*
  • Central Nervous System Diseases / pathology
  • Doublecortin Domain Proteins
  • Gene Expression Regulation / drug effects
  • Humans
  • Microtubule-Associated Proteins / metabolism
  • Neurogenesis / drug effects
  • Neuropeptide Y / metabolism*
  • Neuropeptide Y / pharmacology
  • Neuropeptide Y / therapeutic use*
  • Neuropeptides / metabolism
  • Neuroprotective Agents / metabolism
  • Neuroprotective Agents / pharmacology
  • Neuroprotective Agents / therapeutic use
  • Signal Transduction / drug effects

Substances

  • Doublecortin Domain Proteins
  • Microtubule-Associated Proteins
  • Neuropeptide Y
  • Neuropeptides
  • Neuroprotective Agents