A role for A-to-I RNA editing in temperature adaptation

Physiology (Bethesda). 2012 Dec;27(6):362-9. doi: 10.1152/physiol.00029.2012.

Abstract

A-to-I RNA editing can recode mRNAs, giving organisms the option to express diverse, functionally distinct protein isoforms. Here, we propose that RNA editing is inherently geared for temperature adaptation because it tends to recode to smaller, less stabilizing amino acids. Studies on how editing affects protein function support this idea.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adaptation, Biological / genetics*
  • Animals
  • Humans
  • Protein Isoforms
  • RNA Editing*
  • RNA, Messenger / genetics*
  • Temperature

Substances

  • Protein Isoforms
  • RNA, Messenger