Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA

Paul G Mullins; David J McGonigle; Ruth L O'Gorman; Nicolaas A J Puts; Rishma Vidyasagar; C John Evans; Cardiff Symposium on MRS of GABA; Richard A E Edden

doi:10.1016/j.neuroimage.2012.12.004

Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA

Neuroimage. 2014 Feb 1:86:43-52. doi: 10.1016/j.neuroimage.2012.12.004. Epub 2012 Dec 13.

Authors

Paul G Mullins¹, David J McGonigle², Ruth L O'Gorman³, Nicolaas A J Puts⁴, Rishma Vidyasagar⁵, C John Evans⁶; Cardiff Symposium on MRS of GABA; Richard A E Edden⁴

Collaborators

Cardiff Symposium on MRS of GABA:
Matthew J Brookes, Adrian Garcia, Bradley R Foerster, Myria Petrou, Darren Price, Bhavana S Solanky, Inês R Violante, Steve Williams, Martin Wilson

Affiliations

¹ Bangor Imaging Unit, School of Psychology, Bangor University, Bangor, LL57 2AS, UK. Electronic address: p.mullins@bangor.ac.uk.
² CUBRIC, School of Psychology, Cardiff University, Cardiff, CF10 3AT, UK; School of Biosciences, Cardiff University, Cardiff, CF10 3AT, UK.
³ University Children's Hospital, Steinwiesstrasse 75, 8032 Zürich, Switzerland; Center for Integrative Human Physiology (ZIHP), University of Zürich, Switzerland.
⁴ Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA; F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 North Broadway Street, Room G-25, Baltimore, MD 21205, USA.
⁵ Biomedical Imaging Institute, School of Cancer and Enabling Sciences, Manchester University, Stopford Building, Oxford Road, Manchester, M13 9PL, UK.
⁶ CUBRIC, School of Psychology, Cardiff University, Cardiff, CF10 3AT, UK.

Abstract

There is increasing interest in the use of edited proton magnetic resonance spectroscopy for the detection of GABA in the human brain. At a recent meeting held at Cardiff University, a number of spectroscopy groups met to discuss the acquisition, analysis and interpretation of GABA-edited MR spectra. This paper aims to set out the issues discussed at this meeting, reporting areas of consensus around parameters and procedures in the field and highlighting those areas where differences remain. It is hoped that this paper can fulfill two needs, providing a summary of the current 'state-of-the-art' in the field of GABA-edited MRS at 3T using MEGA-PRESS and a basic guide to help researchers new to the field to avoid some of the pitfalls inherent in the acquisition and processing of edited MRS for GABA.

Keywords: Edited MRS; GABA; MEGA-PRESS; MRS analysis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Algorithms*
Brain / metabolism*
Humans
Magnetic Resonance Spectroscopy / methods*
Reproducibility of Results
Sensitivity and Specificity
gamma-Aminobutyric Acid / metabolism*

Substances

gamma-Aminobutyric Acid

Abstract

Publication types

MeSH terms

Substances

Grants and funding