Abstract
Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.
Publication types
-
Research Support, N.I.H., Extramural
-
Review
MeSH terms
-
Animals
-
Brain / blood supply
-
Brain / metabolism
-
Humans
-
Ischemia / metabolism
-
Ischemia / pathology
-
Neovascularization, Pathologic
-
Neural Stem Cells / cytology
-
Neural Stem Cells / metabolism
-
Neural Stem Cells / transplantation
-
Neurogenesis
-
Stroke / metabolism*
-
Stroke / pathology
-
Stroke / therapy
-
Vascular Endothelial Growth Factor A / genetics
-
Vascular Endothelial Growth Factor A / metabolism*
-
Vascular Endothelial Growth Factor B / metabolism*
-
Vascular Endothelial Growth Factor Receptor-1 / metabolism
-
Vascular Endothelial Growth Factor Receptor-2 / metabolism
Substances
-
Vascular Endothelial Growth Factor A
-
Vascular Endothelial Growth Factor B
-
Vascular Endothelial Growth Factor Receptor-1
-
Vascular Endothelial Growth Factor Receptor-2