Abstract
It is unclear why motor neurons selectively degenerate in amyotrophic lateral sclerosis (ALS). Saxena et al. (2013) demonstrate that excitation of motor neurons can prevent their demise in a mouse model of inherited ALS by a mechanism involving the mTOR pathway.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Intramural
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Comment
MeSH terms
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Amyotrophic Lateral Sclerosis / metabolism*
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Animals
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Male
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Motor Neurons / metabolism*
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Superoxide Dismutase / metabolism*
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Superoxide Dismutase-1
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TOR Serine-Threonine Kinases / metabolism*
Substances
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Sod1 protein, mouse
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Superoxide Dismutase
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Superoxide Dismutase-1
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mTOR protein, mouse
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TOR Serine-Threonine Kinases