Excitation BolsTORs motor neurons in ALS mice

Mark P Mattson

doi:10.1016/j.neuron.2013.09.017

Excitation BolsTORs motor neurons in ALS mice

Neuron. 2013 Oct 2;80(1):1-3. doi: 10.1016/j.neuron.2013.09.017. Epub 2013 Oct 2.

Author

Mark P Mattson¹

Affiliation

¹ Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: mark.mattson@nih.gov.

PMID: 24094096
DOI: 10.1016/j.neuron.2013.09.017

Abstract

It is unclear why motor neurons selectively degenerate in amyotrophic lateral sclerosis (ALS). Saxena et al. (2013) demonstrate that excitation of motor neurons can prevent their demise in a mouse model of inherited ALS by a mechanism involving the mTOR pathway.

Publication types

Research Support, N.I.H., Intramural
Comment

MeSH terms

Amyotrophic Lateral Sclerosis / metabolism*
Animals
Male
Motor Neurons / metabolism*
Superoxide Dismutase / metabolism*
Superoxide Dismutase-1
TOR Serine-Threonine Kinases / metabolism*

Substances

Sod1 protein, mouse
Superoxide Dismutase
Superoxide Dismutase-1
mTOR protein, mouse
TOR Serine-Threonine Kinases

Grants and funding

Intramural NIH HHS/United States