Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes

L C Timpe; T L Schwarz; B L Tempel; D M Papazian; Y N Jan; L Y Jan

doi:10.1038/331143a0

Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes

Nature. 1988 Jan 14;331(6152):143-5. doi: 10.1038/331143a0.

Authors

L C Timpe¹, T L Schwarz, B L Tempel, D M Papazian, Y N Jan, L Y Jan

Affiliation

¹ Howard Hughes Medical Institute, University of California, San Francisco 94143.

PMID: 2448636
DOI: 10.1038/331143a0

Abstract

The Shaker gene of Drosophila melanogaster encodes a potassium-selective ion channel, the 'A' channel, or one of its subunits. A single Shaker messenger RNA species suffices to direct the synthesis of functional A channels in Xenopus oocytes. Physiological characteristics of the A currents induced by two different mRNA species are compared.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
DNA / genetics*
Drosophila melanogaster / genetics*
Injections
Ion Channels / metabolism*
Ion Channels / physiology
Kinetics
Mutation
Oocytes / metabolism*
Potassium / metabolism*
RNA, Messenger / pharmacology
Xenopus / metabolism*

Substances

Ion Channels
RNA, Messenger
DNA
Potassium