Abstract
Several glycoproteins that control blood-cell production and function have been purified and sequenced. The four colony-stimulating factors interact in a complex way to regulate the differentiation and maturation of the granulocyte and macrophage lineages and have potential applications for the clinical manipulation of blood-cell production.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Cell Differentiation
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Cell Division
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Colony-Stimulating Factors / physiology
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Granulocyte Colony-Stimulating Factor
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Granulocyte-Macrophage Colony-Stimulating Factor
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Granulocytes / cytology
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Growth Substances / physiology
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Hematopoietic Stem Cells / cytology*
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Leukemia / pathology
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Macrophages / cytology
Substances
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Colony-Stimulating Factors
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Growth Substances
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Granulocyte Colony-Stimulating Factor
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Granulocyte-Macrophage Colony-Stimulating Factor