Structural and functional correlates of epileptogenesis - does gender matter?

Neurobiol Dis. 2014 Oct:70:69-73. doi: 10.1016/j.nbd.2014.05.028. Epub 2014 Jun 2.

Abstract

In the majority of neuropsychiatric conditions, marked gender-based differences have been found in the epidemiology, clinical manifestations, and therapy of disease. One possible reason is that sex differences in cerebral morphology, structural and functional connections, render men and women differentially vulnerable to various disease processes. The present review addresses this issue with respect to the functional and structural correlates to some forms of epilepsy.

Keywords: Cerebral connectivity; Generalized epilepsy; MRI; MTLE; Seizures; Sex difference.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / physiopathology*
  • Epilepsy / physiopathology*
  • Female
  • Humans
  • Male
  • Sex Characteristics*