Two aspects of ASIC function: Synaptic plasticity and neuronal injury

Neuropharmacology. 2015 Jul:94:42-8. doi: 10.1016/j.neuropharm.2014.12.010. Epub 2015 Jan 9.

Abstract

Extracellular brain pH fluctuates in both physiological and disease conditions. The main postsynaptic proton receptor is the acid-sensing ion channels (ASICs). During the past decade, much progress has been made on protons, ASICs, and neurological disease. This review summarizes the recent progress on synaptic role of protons and our current understanding of how ASICs contribute to various types of neuronal injury in the brain. This article is part of the Special Issue entitled 'Acid-Sensing Ion Channels in the Nervous System'.

Keywords: ASIC; Acidosis; Neuronal injury; Proton; Synaptic plasticity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acid Sensing Ion Channels / metabolism*
  • Animals
  • Brain / metabolism*
  • Humans
  • Nervous System Diseases / metabolism*
  • Neuronal Plasticity / physiology*
  • Neurons / metabolism*

Substances

  • Acid Sensing Ion Channels