Abstract
In cultures of rat cerebral cortex in which astrocyte proliferation was stringently suppressed, glutamate neurotoxicity occurred at glutamate concentrations similar to those which are normally found in the extracellular space in the hippocampus. Concentrations of glutamate one hundred-fold higher were required to produce neurotoxicity in the presence of abundant astrocytes. This suggests that the sensitivity of central neurons to glutamate toxicity may be dependent upon astrocyte function.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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2-Amino-5-phosphonovalerate
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Animals
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Aspartic Acid / analogs & derivatives
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Aspartic Acid / pharmacology
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Astrocytes / physiology*
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Cells, Cultured
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Cerebral Cortex / drug effects*
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Cerebral Cortex / metabolism
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Chromatography, High Pressure Liquid
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Electrophysiology
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Glutamates / toxicity*
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Glycine / pharmacology
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Hippocampus / drug effects
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Hippocampus / metabolism
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Histocytochemistry
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N-Methylaspartate
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Neurons / drug effects
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Neurons / metabolism
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Rats
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter / physiology
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Valine / analogs & derivatives
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Valine / pharmacology
Substances
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Glutamates
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter
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Aspartic Acid
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N-Methylaspartate
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2-Amino-5-phosphonovalerate
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Valine
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Glycine