Dorsal medial prefrontal cortex contributes to conditioned taste aversion memory consolidation and retrieval

Maria Carolina Gonzalez; Maria Eugenia Villar; Lionel M Igaz; Haydée Viola; Jorge H Medina

doi:10.1016/j.nlm.2015.10.007

Dorsal medial prefrontal cortex contributes to conditioned taste aversion memory consolidation and retrieval

Neurobiol Learn Mem. 2015 Dec:126:1-6. doi: 10.1016/j.nlm.2015.10.007. Epub 2015 Oct 19.

Authors

Maria Carolina Gonzalez¹, Maria Eugenia Villar¹, Lionel M Igaz², Haydée Viola¹, Jorge H Medina³

Affiliations

¹ Laboratorio de Memoria, IBCN, UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina.
² Grupo de Neurociencias de Sistemas, IFIBIO Houssay, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina.
³ Laboratorio de Memoria, IBCN, UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina; Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina. Electronic address: jmedina@fmed.uba.ar.

PMID: 26493441
DOI: 10.1016/j.nlm.2015.10.007

Abstract

The medial prefrontal cortex (mPFC) is known for its role in decision making and memory processing, including the participation in the formation of extinction memories. However, little is known regarding its contribution to aversive memory consolidation. Here we demonstrate that neural activity and protein synthesis are required in the dorsal mPFC for memory formation of a conditioned taste aversion (CTA) task and that this region is involved in the retrieval of recent and remote long-term CTA memory. In addition, both NMDA receptor and CaMKII activity in dorsal mPFC are needed for CTA memory consolidation, highlighting the complexity of mPFC functions.

Keywords: APV; Muscimol; NMDA receptor; Neural activity; Protein synthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Benzylamines / administration & dosage
Calcium-Calmodulin-Dependent Protein Kinase Type 2 / physiology
Conditioning, Psychological / drug effects
Conditioning, Psychological / physiology
Emetine / administration & dosage
GABA-A Receptor Agonists / administration & dosage
Male
Memory Consolidation / drug effects
Memory Consolidation / physiology*
Mental Recall / drug effects
Mental Recall / physiology*
Muscimol / administration & dosage
Prefrontal Cortex / drug effects
Prefrontal Cortex / metabolism
Prefrontal Cortex / physiology*
Protein Synthesis Inhibitors / administration & dosage
Rats, Wistar
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate / physiology
Signal Transduction / drug effects
Sulfonamides / administration & dosage
Taste Perception / drug effects
Taste Perception / physiology*
Valine / administration & dosage
Valine / analogs & derivatives

Substances

Benzylamines
GABA-A Receptor Agonists
Protein Synthesis Inhibitors
Receptors, N-Methyl-D-Aspartate
Sulfonamides
KN 93
Muscimol
2-amino-5-phosphopentanoic acid
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Valine
Emetine