Amyloid precursor protein processing and bioenergetics

Brain Res Bull. 2017 Jul:133:71-79. doi: 10.1016/j.brainresbull.2016.08.009. Epub 2016 Aug 18.

Abstract

The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form Aβ, and how Aβ generates oligomers, protofibrils, and fibrils. Numerous signaling pathways and changes in cell physiology are known to influence APP processing. Existing data additionally indicate a relationship exists between mitochondria, bioenergetics, and APP processing. Here, we review data that address whether mitochondrial function and bioenergetics modify APP processing and Aβ production.

Keywords: Alpha secretase; Alzheimer's disease; Amyloid beta; Amyloid precursor protein; BACE1; Bioenergetics; Gamma secretase; Mitochondria.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / metabolism
  • Alzheimer Disease / physiopathology
  • Amyloid Precursor Protein Secretases / metabolism
  • Amyloid beta-Peptides / biosynthesis
  • Amyloid beta-Peptides / metabolism
  • Amyloid beta-Protein Precursor / biosynthesis*
  • Amyloid beta-Protein Precursor / metabolism*
  • Amyloid beta-Protein Precursor / pharmacology
  • Animals
  • Energy Metabolism / physiology
  • Humans
  • Mitochondria / physiology
  • Signal Transduction

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Amyloid Precursor Protein Secretases