Abstract
The depletion of mesolimbic dopamine by 6-hydroxydopamine injections into the A10 region of the ventral tegmental area effectively blocked locomotor hyperactivity induced by SKF 10,047, phencyclidine and amphetamine, whereas the stimulatory effects of caffeine and scopolamine were not altered by the lesion. These results suggest that SKF 10,047, like amphetamine, and phencyclidine acts through presynaptic dopaminergic mechanisms in the mesolimbic nucleus accumbens system to stimulate locomotor behavior.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amphetamine / pharmacology
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Animals
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Apomorphine / pharmacology
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Caffeine / pharmacology
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Central Nervous System Stimulants / pharmacology*
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Dopamine / physiology*
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Hydroxydopamines / pharmacology
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Male
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Motor Activity / drug effects*
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Oxidopamine
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Phenazocine / analogs & derivatives*
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Phenazocine / pharmacology
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Phencyclidine / pharmacology*
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Rats
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Rats, Inbred Strains
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Scopolamine / pharmacology
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Tegmentum Mesencephali / drug effects*
Substances
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Central Nervous System Stimulants
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Hydroxydopamines
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Caffeine
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SK&F 10047
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Oxidopamine
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Amphetamine
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Scopolamine
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Phenazocine
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Phencyclidine
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Apomorphine
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Dopamine