Abstract
In post-mortem brain specimens from patients dying with a clinical diagnosis of Huntington's disease (HD) immunohistochemistry showed a substantial loss from the neostriatum of neurons containing the calcium-binding protein calbindin 28K. These calbindin neurons, and the straital compartment in which they are sited, are particularly damaged in HD, suggesting that a failure of calcium buffering or homeostasis may contribute to cell death in HD.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Aged
-
Brain Chemistry*
-
Calcium-Binding Proteins / analysis*
-
Corpus Striatum / analysis*
-
Corpus Striatum / pathology
-
Female
-
Humans
-
Huntington Disease / pathology*
-
Immunohistochemistry
-
Male
-
Middle Aged
-
Neurons / analysis*
-
Neurons / pathology
-
Substantia Nigra / analysis
-
Substantia Nigra / pathology
Substances
-
Calcium-Binding Proteins
-
calcium-binding protein (brain)