Learning impairment in rats by N-methyl-D-aspartate receptor antagonists

Neuropharmacology. 1988 Jun;27(6):653-6. doi: 10.1016/0028-3908(88)90189-x.

Abstract

2-Amino-5-phosphonovalerate (APV, icv) phencyclidine (PCP, ip) and scopolamine (sc) dose-dependently disrupted short term working memory in radial maze. These drugs injected before, but not after training attenuated retention of long term memory in passive avoidance task. A relation of PCP action to its antagonism at NMDA receptors may be suggested.

MeSH terms

  • 2-Amino-5-phosphonovalerate
  • Animals
  • Anticonvulsants / administration & dosage
  • Anticonvulsants / pharmacology*
  • Avoidance Learning / drug effects
  • Injections, Intraventricular
  • Learning / drug effects*
  • Male
  • Phencyclidine / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter / drug effects*
  • Scopolamine / pharmacology*
  • Valine / administration & dosage
  • Valine / analogs & derivatives*
  • Valine / pharmacology

Substances

  • Anticonvulsants
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter
  • 2-Amino-5-phosphonovalerate
  • Scopolamine
  • Valine
  • Phencyclidine