Prothymosin alpha is a nuclear protein

J D Watts; P D Cary; C Crane-Robinson

doi:10.1016/0014-5793(89)80182-6

Prothymosin alpha is a nuclear protein

FEBS Lett. 1989 Mar 13;245(1-2):17-20. doi: 10.1016/0014-5793(89)80182-6.

Authors

J D Watts¹, P D Cary, C Crane-Robinson

Affiliation

¹ Biophysics Laboratories, Portsmouth Polytechnic, England.

PMID: 2924919
DOI: 10.1016/0014-5793(89)80182-6

Abstract

The cellular location of the so-called 'thymic hormone' prothymosin alpha has been studied by microinjection into the cytoplasm of Xenopus oocytes, followed by separate monitoring of nuclear and cytoplasmic concentrations. It is shown that prothymosin alpha migrates to the nucleus at a rate comparable to that of histone H1. Prothymosin alpha cannot therefore be a hormone in the usual sense of the word.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cattle
Cell Nucleus / metabolism*
Cytoplasm / metabolism
Electrophoresis, Polyacrylamide Gel
Female
Iodine Radioisotopes
Kinetics
Microinjections
Oocytes / ultrastructure
Protein Precursors / metabolism*
Thymosin / analogs & derivatives*
Thymosin / metabolism
Thymus Gland / analysis
Xenopus laevis

Substances

Iodine Radioisotopes
Protein Precursors
prothymosin alpha
Thymosin