Changes in voltage dependence of NMDA currents during development

Neurosci Lett. 1988 Nov 22;94(1-2):88-92. doi: 10.1016/0304-3940(88)90275-3.

Abstract

N-Methyl-D-aspartate (NMDA), applied by superfusion to hippocampal slices evokes comparable peak inward currents in CA3 pyramidal cells of adult and 0-10 day-old rats. However, NMDA current-voltage plots from immature neurones do not consistently show the region of negative slope conductance characteristic of adult. Therefore at a critical stage of development, NMDA activation may elicit substantial inward currents and Ca2+ influx at resting membrane potential.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging
  • Animals
  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / pharmacology
  • Electric Conductivity
  • Hippocampus / drug effects
  • Hippocampus / growth & development*
  • Hippocampus / physiology
  • In Vitro Techniques
  • Membrane Potentials / drug effects
  • N-Methylaspartate
  • Neurons / drug effects
  • Neurons / physiology
  • Rats
  • Rats, Inbred Strains

Substances

  • Aspartic Acid
  • N-Methylaspartate