Abstract
Intrathecal administration of PGE2 and PGF2 alpha and intradermal administration of PGE2 but not PGF2 alpha, in low doses, produce hyperalgesia as measured by the Randall-Selitto paw-withdrawal test. Indomethacin (2 mg/kg, i.p.) prevented intrathecal PGF2 alpha, but not PGE2-induced hyperalgesia. We propose that the central nociceptive effects of PGF2 alpha are mediated, indirectly, by effecting the cyclo-oxygenation of arachidonic acid in the central nervous system.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Arachidonic Acid
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Arachidonic Acids / metabolism
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Central Nervous System / metabolism
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Dinoprost
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Dinoprostone
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Indomethacin / pharmacology*
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Injections, Intraperitoneal
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Injections, Spinal
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Male
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Pain / chemically induced*
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Prostaglandin-Endoperoxide Synthases / metabolism
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Prostaglandins E / pharmacology*
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Prostaglandins F / antagonists & inhibitors*
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Rats
Substances
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Arachidonic Acids
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Prostaglandins E
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Prostaglandins F
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Arachidonic Acid
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Dinoprost
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Prostaglandin-Endoperoxide Synthases
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Dinoprostone
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Indomethacin