Complement depletion suppresses Lewis rat experimental allergic neuritis

T E Feasby; J J Gilbert; A F Hahn; M Neilson

doi:10.1016/0006-8993(87)90572-5

Complement depletion suppresses Lewis rat experimental allergic neuritis

Brain Res. 1987 Sep 1;419(1-2):97-103. doi: 10.1016/0006-8993(87)90572-5.

Authors

T E Feasby¹, J J Gilbert, A F Hahn, M Neilson

Affiliation

¹ Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.

PMID: 3499953
DOI: 10.1016/0006-8993(87)90572-5

Abstract

Lewis rats immunized with myelin and complete Freund's adjuvant were treated with cobra venom factor (CVF) which depletes the C3 component of complement. CVF given at day 9 delayed the onset of experimental allergic neuritis (EAN) by 2-3 days and when given at days 9 and 12 delayed the onset of EAN by 4-5 days. Lumbar nerve roots of CVF-treated rats had significantly less demyelination than those from control EAN rats.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cobra Neurotoxin Proteins
Complement Activation / drug effects
Complement C3 / blood
Complement C3 / immunology*
Freund's Adjuvant
Male
Neuritis, Autoimmune, Experimental / immunology*
Neuritis, Autoimmune, Experimental / physiopathology
Rats
Rats, Inbred Lew
Spinal Nerve Roots / immunology
Spinal Nerve Roots / pathology
Time Factors

Substances

Cobra Neurotoxin Proteins
Complement C3
Freund's Adjuvant