A microcomputer-based method for physiologically interpretable measurement of the rewarding efficacy of brain stimulation

Physiol Behav. 1985 Sep;35(3):395-403. doi: 10.1016/0031-9384(85)90315-4.

Abstract

Determination of the function relating rate of pressing to the number of pulses in a train of fixed duration (the rate-frequency function) yields a physiologically interpretable measure of changes in the rewarding efficacy of the stimulation, because the number of action potentials in the reward-relevant first stage axons is directly proportional to the number of pulses in the train. We describe a system, based on a low cost microcomputer, which permits determination of 16-data-point rate-frequency functions in 4-6 animals simultaneously in less than 10 minutes. We give an empirical and theoretical justification for using the curve-shift measurement procedure in drug and lesion work, where the experimental treatments must be presumed to have substantial effects on performance factors.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / physiology*
  • Brain Mapping / instrumentation
  • Brain Mapping / methods*
  • Computers*
  • Microcomputers*
  • Psychometrics
  • Psychopharmacology / methods*
  • Psychophysiology / methods*
  • Rats
  • Reward*
  • Self Stimulation / drug effects
  • Self Stimulation / physiology*
  • Software