Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats

Am J Physiol. 1985 Nov;249(5 Pt 2):R638-41. doi: 10.1152/ajpregu.1985.249.5.R638.

Abstract

Selective section of afferent vagal axons that reach below the diaphragm blocks the satiating effect of peripherally administered cholecystokinin in the rat. Section of the analogous efferent axons has no effect. After the behavioral tests, the selective axonal sections were confirmed with horseradish peroxidase histochemistry.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abdomen
  • Animals
  • Axons / physiology*
  • Eating / drug effects
  • Male
  • Neurons, Afferent / physiology*
  • Neurons, Afferent / ultrastructure
  • Rats
  • Rats, Inbred Strains
  • Satiation / physiology*
  • Satiety Response / physiology*
  • Sincalide / pharmacology*
  • Vagus Nerve / physiology*

Substances

  • Sincalide