The membrane concentrations of neutral and positive anesthetics (alcohols, chlorpromazine, morphine) fit the Meyer-Overton rule of anesthesia; negative narcotics do not

Biochim Biophys Acta. 1972 Jan 17;255(1):207-19. doi: 10.1016/0005-2736(72)90023-5.
No abstract available

MeSH terms

  • Alcohols / metabolism
  • Anesthetics / metabolism*
  • Anesthetics / pharmacology
  • Animals
  • Barbiturates / metabolism
  • Carbon Isotopes
  • Cell Membrane / metabolism
  • Chlorpromazine / metabolism
  • Erythrocytes / cytology
  • Erythrocytes / drug effects
  • Erythrocytes / metabolism*
  • Fatty Acids, Nonesterified / metabolism
  • Guinea Pigs
  • Hemolysis / drug effects
  • Humans
  • Membranes / metabolism*
  • Morphine / metabolism
  • Nerve Endings / metabolism*
  • Phenols / metabolism
  • Procaine / metabolism
  • Rabbits
  • Sarcoplasmic Reticulum / metabolism*
  • Sulfur Isotopes
  • Synaptic Vesicles / metabolism*
  • Synaptosomes / cytology
  • Synaptosomes / metabolism
  • Valerates / metabolism

Substances

  • Alcohols
  • Anesthetics
  • Barbiturates
  • Carbon Isotopes
  • Fatty Acids, Nonesterified
  • Phenols
  • Sulfur Isotopes
  • Valerates
  • Procaine
  • Morphine
  • Chlorpromazine