Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat

F F Johansen; M B Jørgensen; D K Ekström von Lubitz; N H Diemer

doi:10.1016/0006-8993(84)91272-1

Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat

Brain Res. 1984 Jan 23;291(2):373-7. doi: 10.1016/0006-8993(84)91272-1.

Authors

F F Johansen, M B Jørgensen, D K Ekström von Lubitz, N H Diemer

PMID: 6141837
DOI: 10.1016/0006-8993(84)91272-1

Abstract

In this study of the rat hippocampal CA1 stratum radiatum 4 days after 20 min transient cerebral ischaemia, we demonstrated ultrastructural dendritic degeneration and loss, whereas most axons appeared undamaged. Autoradiographs 4 days after ischaemia showed unchanged Na+-dependent glutamate high affinity uptake. The role of glutamate and Ca2+ for this selective postsynaptic vulnerability is discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Axons / ultrastructure
Calcium / metabolism
Dendrites / ultrastructure
Glutamates / metabolism*
Glutamic Acid
Hippocampus / metabolism
Hippocampus / pathology*
Ischemic Attack, Transient / metabolism
Ischemic Attack, Transient / pathology*
Male
Microscopy, Electron
Rats
Rats, Inbred Strains

Substances

Glutamates
Glutamic Acid
Calcium