Abstract
In rat tail artery the electrical response to nerve stimulation was biphasic, consisting of a fast, transient depolarisation which was resistant to alpha-adrenoceptor antagonists and a slow, prolonged depolarisation which was abolished by them. In the presence of alpha, beta-methylene-adenosine 5'-triphosphate (alpha, beta-methylene-ATP), which abolishes responses mediated via P2-purinoceptors, the fast depolarisation was abolished, whilst the slow depolarisation persisted. We propose that both adenosine 5'-triphosphate (ATP) and noradrenaline (NA) are involved in sympathetic neurotransmission in the rat tail artery.
MeSH terms
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Adenosine Triphosphate / analogs & derivatives
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Adenosine Triphosphate / pharmacology
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Adenosine Triphosphate / physiology*
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Animals
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Arteries / innervation
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Arteries / physiology*
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Electric Stimulation
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In Vitro Techniques
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Muscle Contraction / drug effects
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Muscle, Smooth, Vascular / physiology
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Neurotransmitter Agents / physiology*
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Phentolamine / pharmacology
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Rats
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Receptors, Neurotransmitter / drug effects
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Receptors, Neurotransmitter / physiology*
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Receptors, Purinergic
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Sympathetic Nervous System / drug effects
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Sympathetic Nervous System / physiology
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Tail / blood supply
Substances
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Neurotransmitter Agents
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Receptors, Neurotransmitter
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Receptors, Purinergic
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Adenosine Triphosphate
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alpha,beta-methyleneadenosine 5'-triphosphate
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Phentolamine