Abstract
Studies on the uptake and storage of sodium and biogenic amines (phenylethylamine, noradrenaline, histamine) by two weak cation-exchangers, IRC-50 and Sephadex C-50, and by biogenic granule-enriched preparations demonstrated that the synthetic and biogenic materials had several common characteristics. They showed similar concentration- and pH-dependence and fitted the same cation-exchange and receptor-binding equations. The observations were taken to support the view that the matrices of amine-storing granules have the properties of weak cation-exchangers, with carboxyls as the cation-binding groups.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anion Exchange Resins / pharmacology
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Biogenic Amines / metabolism*
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Cation Exchange Resins / pharmacology*
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Cattle
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Chromaffin Granules / metabolism
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Cytoplasmic Granules / metabolism*
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Dextrans / pharmacology
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Histamine / metabolism
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Hydrogen-Ion Concentration
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Ion Exchange Resins / pharmacology*
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Mast Cells / metabolism
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Neurons / metabolism
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Norepinephrine / metabolism
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Phenethylamines / metabolism
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Resins, Synthetic
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Sodium / metabolism*
Substances
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Anion Exchange Resins
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Biogenic Amines
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Cation Exchange Resins
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Dextrans
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Ion Exchange Resins
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Phenethylamines
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Resins, Synthetic
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Histamine
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Amberlite IRC50
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sephadex
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Sodium
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Norepinephrine