Abstract
The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active neuromas.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Aminopyridine
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Afferent Pathways / physiopathology
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Aminopyridines / pharmacology
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Animals
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Axons / physiology
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Evoked Potentials / drug effects
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Ion Channels / physiology*
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Male
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Muridae
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Nerve Regeneration* / drug effects
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Neuroma / physiopathology*
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Potassium / metabolism
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Sciatic Nerve / physiopathology
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Synaptic Transmission* / drug effects
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Tetraethylammonium
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Tetraethylammonium Compounds / pharmacology
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Tibial Nerve / physiopathology
Substances
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Aminopyridines
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Ion Channels
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Tetraethylammonium Compounds
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Tetraethylammonium
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4-Aminopyridine
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Potassium