Abstract
Severe or even mild hyperhomocysteinaemia can cause a wide range of neurological problems. In recent years its vascular complications, including cerebral stroke, in children and young adults have gained special interest, because hyperhomocysteinaemia is treatable and recurrence of vascular incidents may be preventable. Current knowledge about biochemical mechanisms leading to hyperhomocysteinaemia, the pathogenesis of vascular pathology and neurological disfunction, and the various patterns of cerebral damage are reviewed. The significance of MRI in diagnosis, follow-up and research on hyperhomocysteinaemia is discussed.
MeSH terms
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Adolescent
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Adult
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Amino Acid Metabolism, Inborn Errors / diagnosis*
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Amino Acid Metabolism, Inborn Errors / pathology
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Amino Acid Metabolism, Inborn Errors / therapy
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Brain / pathology
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Brain Diseases, Metabolic / diagnosis*
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Brain Diseases, Metabolic / pathology
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Brain Diseases, Metabolic / therapy
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Cerebral Angiography*
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Child
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Demyelinating Diseases / diagnosis
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Demyelinating Diseases / pathology
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Demyelinating Diseases / therapy
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Female
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Homocysteine / blood*
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Humans
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Intracranial Arteriosclerosis / diagnosis
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Intracranial Arteriosclerosis / pathology
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Intracranial Arteriosclerosis / therapy
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Magnetic Resonance Imaging*
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Male