Abstract
In vivo microdialysis was used to assess the hypothesis that the stress-induced increase in dopamine release in the prefrontal cortex is mediated by stress-activated glutamate neurotransmission in this region. Local perfusion of an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione, blocked the stress-induced increase in dopamine levels, whereas an NMDA receptor antagonist, 2-amino-5-phosphonopentanoic acid, at the dose tested, was not able to alter this response significantly. These data indicate that the effect of stress on dopamine release in the prefrontal cortex is mediated locally by activation of AMPA/kainate receptors, which modulate the release of dopamine in this region.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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2-Amino-5-phosphonovalerate / pharmacology*
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6-Cyano-7-nitroquinoxaline-2,3-dione
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Analysis of Variance
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Animals
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Dopamine / metabolism*
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Excitatory Amino Acid Antagonists*
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Extracellular Space / drug effects
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Extracellular Space / metabolism
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Male
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Microdialysis / methods
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Pain
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Prefrontal Cortex / drug effects
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Prefrontal Cortex / metabolism*
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Quinoxalines / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Receptors, AMPA / antagonists & inhibitors
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Receptors, Glutamate / physiology
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Receptors, Kainic Acid / antagonists & inhibitors
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
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Stress, Psychological / metabolism*
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / pharmacology*
Substances
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Excitatory Amino Acid Antagonists
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Quinoxalines
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Receptors, AMPA
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Receptors, Glutamate
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Receptors, Kainic Acid
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Receptors, N-Methyl-D-Aspartate
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6-Cyano-7-nitroquinoxaline-2,3-dione
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2-Amino-5-phosphonovalerate
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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Dopamine