NCAM-antibodies modulate induction of long-term potentiation in rat hippocampal CA1

L C Rønn; E Bock; D Linnemann; H Jahnsen

doi:10.1016/0006-8993(95)00147-i

NCAM-antibodies modulate induction of long-term potentiation in rat hippocampal CA1

Brain Res. 1995 Apr 17;677(1):145-51. doi: 10.1016/0006-8993(95)00147-i.

Authors

L C Rønn¹, E Bock, D Linnemann, H Jahnsen

Affiliation

¹ University of Copenhagen, Protein Laboratory, Panum Institute, Denmark.

PMID: 7606459
DOI: 10.1016/0006-8993(95)00147-i

Abstract

The neural cell adhesion molecule (NCAM) probably plays a role in neural plasticity in the adult vertebrate brain. We here present evidence that NCAM may be involved in long-term potentiation (LTP) in the CA1-region of rat hippocampal slices. It is shown that local application of antibodies against NCAM inhibits subsequent LTP-induction. Thus NCAM may be directly involved in the initial phase of LTP-induction. These results have important implications for the possible involvement of NCAM in learning and memory.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

2-Amino-5-phosphonovalerate / pharmacology
Animals
Antibodies / immunology*
Cell Adhesion Molecules, Neuronal / immunology
Cell Adhesion Molecules, Neuronal / physiology*
Diffusion
Hippocampus / physiology*
Immunohistochemistry
In Vitro Techniques
Long-Term Potentiation / physiology*
Male
Microinjections
Neural Pathways / drug effects
Neural Pathways / physiology
Rats
Rats, Wistar

Substances

Antibodies
Cell Adhesion Molecules, Neuronal
2-Amino-5-phosphonovalerate