An avian model for the reversal of 6-hydroxydopamine induced rotating behaviour by neural grafting

Neurosci Lett. 1995 Mar 10;187(3):153-6. doi: 10.1016/0304-3940(95)11361-y.

Abstract

A new animal model of parkinsonism was established in 'Black Silkie' chickens by means of unilateral injections of 6-hydroxy-dopamine into the substantia nigra. Apomorphine produced a strong contralateral turning pattern in the lesioned chickens, amphetamine had no effect. 6-OHDA treated animals received embryonic transplants of substantia nigra cell suspensions which caused them to cease rotating (P < 0.01). This finding allows us to add an avian model, which offers unique methodological advantages, for reversal of 6-OHDA-induced rotating behavior by transplantation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Brain Tissue Transplantation*
  • Cell Transplantation
  • Chickens
  • Disease Models, Animal*
  • Immunohistochemistry
  • Male
  • Neurons / transplantation*
  • Oxidopamine / pharmacology*
  • Parkinson Disease / surgery
  • Time Factors

Substances

  • Oxidopamine