Abstract
Many growth factors and cytokines promote receptor clustering on binding. At least three different protein-protein interaction sites are involved: cytokine-receptor I, cytokine-receptor II and receptor I-receptor II. Although structural data on these complexes are limited, recent structural and mutagenesis studies of the four-helix bundle class of cytokines are clarifying the nature of the complexes formed.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Cytokines / chemistry
-
Cytokines / metabolism
-
Growth Substances / chemistry*
-
Growth Substances / metabolism*
-
Humans
-
Protein Conformation*
-
Receptors, Cytokine / chemistry
-
Receptors, Cytokine / metabolism
-
Receptors, Growth Factor / chemistry*
-
Receptors, Growth Factor / metabolism*
Substances
-
Cytokines
-
Growth Substances
-
Receptors, Cytokine
-
Receptors, Growth Factor