Abstract
Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K+) channel, IKACh. Activated muscarinic receptors stimulate IKACh via the G-protein beta gamma-subunits. It has been assumed that the inwardly rectifying K(+)-channel gene, GIRK1, alone encodes IKACh. It is now shown that IKACh is a heteromultimer of two distinct inwardly rectifying K(+)-channel subunits, GIRK1 and a newly cloned member of the family, CIR.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Cell Line
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Cloning, Molecular
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Dogs
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G Protein-Coupled Inwardly-Rectifying Potassium Channels
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GTP-Binding Proteins / metabolism
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Ion Channel Gating
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Membrane Potentials
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Molecular Sequence Data
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Myocardium / metabolism*
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Oocytes
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Potassium Channels / chemistry*
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Potassium Channels / genetics
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Potassium Channels / metabolism*
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Potassium Channels, Inwardly Rectifying*
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Protein Conformation
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Rats
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Recombinant Proteins
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Xenopus
Substances
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G Protein-Coupled Inwardly-Rectifying Potassium Channels
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Kcnj5 protein, rat
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Potassium Channels
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Potassium Channels, Inwardly Rectifying
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Recombinant Proteins
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GTP-Binding Proteins