Abstract
A complementary DNA clone encoding a transporter for glutamate has been isolated from mouse brain, and its functional properties have been examined in Xenopus oocytes. The transporter displays high affinity for glutamate (Km = 72 microM) and is dependent on external Na+. The cDNA sequence predicts a protein of 543 amino acids with 6 potential transmembrane domains. Northern blot analysis indicates the mRNA encoding the glutamate transporter is expressed both in the brain and in peripheral tissues.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Amino Acid Transport System X-AG
-
Animals
-
Base Sequence
-
Blotting, Northern
-
Brain Chemistry / physiology*
-
Cloning, Molecular
-
DNA, Complementary / metabolism
-
DNA-Directed RNA Polymerases / metabolism
-
Glutamates / metabolism
-
Glutamic Acid
-
Glycoproteins / biosynthesis*
-
Glycoproteins / metabolism
-
Mice
-
Mice, Inbred BALB C
-
Molecular Sequence Data
-
Oocytes / metabolism
-
RNA, Messenger / biosynthesis
-
Rats
-
Sodium / physiology
-
Xenopus
Substances
-
Amino Acid Transport System X-AG
-
DNA, Complementary
-
Glutamates
-
Glycoproteins
-
RNA, Messenger
-
Glutamic Acid
-
Sodium
-
DNA-Directed RNA Polymerases