Abstract
The potassium and sodium currents in acutely isolated neostriatal neurons are modulated by activation of both D1- and D2-class receptors. The amplification of mRNA in individual neurons supports this conclusion and has shown that striatonigral neurons express not only D1 and D2 receptors, but D3 receptors as well. The characteristics of the modulations produced by these receptors provide a foundation for both antagonistic and synergistic actions of D1 and D2 agonists in the neostriatum. Understanding precisely how these modulations interact in shaping excitability, however, will require a better characterization of spatial domains in which they operate.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
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Animals
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Bromocriptine / pharmacology
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Dopamine Agents / pharmacology
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Embryo, Mammalian
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Ergolines / pharmacology
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In Vitro Techniques
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Neostriatum / physiology*
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Neurons / drug effects
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Neurons / physiology*
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Potassium Channels / drug effects
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Potassium Channels / physiology*
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Quinpirole
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RNA, Messenger / metabolism
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Rats
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Receptors, Dopamine D1 / biosynthesis
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Receptors, Dopamine D1 / drug effects
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Receptors, Dopamine D1 / physiology*
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Receptors, Dopamine D2 / biosynthesis
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Receptors, Dopamine D2 / drug effects
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Receptors, Dopamine D2 / physiology*
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Sodium Channels / drug effects
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Sodium Channels / physiology*
Substances
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Dopamine Agents
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Ergolines
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Potassium Channels
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RNA, Messenger
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Sodium Channels
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Quinpirole
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Bromocriptine
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine