Abstract
The methyl CpG binding proteins (MeCP1 and MeCP2) are a class of proteins that bind to templates containing symmetrically methylated CpGs. Using an interspecific backcross segregating a number of X-linked markers, we have localized the Mecp2 gene in mouse to the X chromosome close to the microsatellite marker DXMit1. Detailed physical mapping utilizing an available YAC contig encompassing the DXMit1 locus has localized the Mecp2 gene to a 40-kb region between the L1cam and the Rsvp loci, indicating the probable position of a homologue on the human X chromosome.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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Chromosomal Proteins, Non-Histone*
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Chromosome Mapping*
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Chromosomes, Artificial, Yeast
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Crosses, Genetic
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DNA Primers / genetics
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DNA-Binding Proteins / genetics*
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Female
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Humans
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Male
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Methyl-CpG-Binding Protein 2
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Mice
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Mice, Inbred C57BL
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Molecular Sequence Data
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Muridae
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Repressor Proteins*
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Species Specificity
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X Chromosome*
Substances
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Chromosomal Proteins, Non-Histone
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DNA Primers
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DNA-Binding Proteins
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MECP2 protein, human
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Mecp2 protein, mouse
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Methyl-CpG-Binding Protein 2
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Repressor Proteins