Abstract
Neonatal and adult respiratory-related functions of brain stem were compared using in vivo or in vitro approaches. The control of inspiratory off-switch by glutamate-like neurotransmitters was found active at birth. However, neurons from the nucleus tractus solitarius (NTS) are immature at birth because they present growth cones and the transient potassium current appears progressively during the first week of life in association with modification of the dendritic tree. These data support the hypothesis that the mechanisms of respiratory rhythmogenesis are different at birth and in the adult.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Brain Stem / anatomy & histology
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Brain Stem / growth & development*
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Brain Stem / physiology*
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Cats
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Dizocilpine Maleate / pharmacology
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Electrophysiology
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In Vitro Techniques
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Neurons / physiology
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
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Receptors, N-Methyl-D-Aspartate / physiology
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Respiration / physiology*
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Respiratory Center / anatomy & histology
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Respiratory Center / growth & development*
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Respiratory Center / physiology*
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Solitary Nucleus / anatomy & histology
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Solitary Nucleus / growth & development
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Solitary Nucleus / physiology
Substances
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Receptors, N-Methyl-D-Aspartate
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Dizocilpine Maleate