Abstract
The effects of aging on brain dopamine transporters was evaluated in 26 healthy male volunteers (age range, 21-63 years) using positron emission tomography and [11C]cocaine. The ratio of the distribution volume for [11C]cocaine in basal ganglia to that in cerebellum was used as a model parameter for dopamine transporter availability and showed a significant negative correlation with age (r = 0.65, p < 0.0005). This results document an age-related decline in dopamine transporters in healthy individuals.
Publication types
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Adult
-
Aging / metabolism*
-
Basal Ganglia / metabolism
-
Biological Transport
-
Brain / diagnostic imaging
-
Brain / metabolism*
-
Carrier Proteins
-
Cerebellum / metabolism
-
Cocaine / metabolism
-
Dopamine / metabolism*
-
Dopamine Plasma Membrane Transport Proteins
-
Humans
-
Male
-
Membrane Glycoproteins*
-
Membrane Transport Proteins*
-
Middle Aged
-
Nerve Tissue Proteins*
-
Radionuclide Imaging
Substances
-
Carrier Proteins
-
Dopamine Plasma Membrane Transport Proteins
-
Membrane Glycoproteins
-
Membrane Transport Proteins
-
Nerve Tissue Proteins
-
Cocaine
-
Dopamine