Automatic detection of spontaneous synaptic responses in central neurons

N Ankri; P Legendre; D S Faber; H Korn

doi:10.1016/0165-0270(94)90060-4

Automatic detection of spontaneous synaptic responses in central neurons

J Neurosci Methods. 1994 Apr;52(1):87-100. doi: 10.1016/0165-0270(94)90060-4.

Authors

N Ankri¹, P Legendre, D S Faber, H Korn

Affiliation

¹ Laboratoire de Neurobiologie Cellulaire, INSERM U 261, Département des Biotechnologies, Institut Pasteur, Paris, France.

PMID: 8090022
DOI: 10.1016/0165-0270(94)90060-4

Abstract

A fully automatized software package for detection and measurements of randomly occurring synaptic transients embedded in background noise is described. It is based on waveform recognition protocols, allows analysis of long data segments, and provides quantitative information about event amplitudes and kinetics. Simulated postsynaptic recordings have been used to assess its performance over a wide range of conditions mimicking those seen in physiological experiments.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Artifacts
Brain / physiology*
Computer Simulation
Electronic Data Processing*
Humans
Models, Neurological
Neurons / physiology*
Software
Synapses / physiology*