Abstract
Levels of CSF fluid interleukin-2, but not interleukin-1 alpha, were found to be higher in 10 neuroleptic-free schizophrenic patients than in 10 healthy subjects matched for sex and age. Because interleukin-2 increases dopaminergic neurotransmission and participates in autoimmunity and cell growth, the authors postulate that elevated levels of central interleukin-2 might contribute to the increased dopaminergic neurotransmission, autoimmune phenomena, and abnormal brain morphology described in some patients with schizophrenia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antipsychotic Agents / pharmacology
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Autoimmunity
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Dopamine / physiology
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Enzyme-Linked Immunosorbent Assay
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Humans
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Interleukin-1 / cerebrospinal fluid
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Interleukin-2 / cerebrospinal fluid*
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Male
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Middle Aged
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Receptors, Dopamine / drug effects
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Schizophrenia / cerebrospinal fluid*
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Schizophrenia / immunology
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Schizophrenia / physiopathology
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Stress, Physiological / immunology
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Synaptic Transmission
Substances
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Antipsychotic Agents
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Interleukin-1
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Interleukin-2
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Receptors, Dopamine
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Dopamine