Postnatal changes in [3H]mazindol-labelled dopamine uptake sites in the rat striatum following prenatal cocaine exposure

A Stadlin; H L Choi; D Tsang

doi:10.1016/0006-8993(94)91259-9

Postnatal changes in [3H]mazindol-labelled dopamine uptake sites in the rat striatum following prenatal cocaine exposure

Brain Res. 1994 Feb 21;637(1-2):345-8. doi: 10.1016/0006-8993(94)91259-9.

Authors

A Stadlin¹, H L Choi, D Tsang

Affiliation

¹ Department of Anatomy, Chinese University of Hong Kong, Shatin, New Territories.

PMID: 8180817
DOI: 10.1016/0006-8993(94)91259-9

Abstract

The present study showed that prenatal cocaine exposure (60 mg/kg/day) has a transient effect on the [3H]mazindol-labelled dopamine uptake sites in the striatum of the rat offspring examined from postnatal week 0-32. There is a 39% and 21% decrease in the number of binding sites (Bmax) in the cocaine-exposed group at postnatal weeks 3 and 4, respectively, with a recovery to near normal values by postnatal week 8.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Birth Weight / drug effects
Cocaine / pharmacology*
Female
Mazindol / pharmacokinetics
Mazindol / pharmacology*
Neostriatum / drug effects
Neostriatum / metabolism*
Pregnancy
Prenatal Exposure Delayed Effects*
Rats
Rats, Sprague-Dawley
Receptors, Dopamine / drug effects*
Weight Gain / drug effects

Substances

Receptors, Dopamine
Mazindol
Cocaine